Our Science


Papyrus Therapeutics

OPCML Tumor Supression

  • OPCML tumor suppressor therapy effectively replaces a crucial protein that blocks cancer in almost half of all human cancers
  • OPCML therapy acts at the cell surface, without the need to restore the tumor suppressor inside every cancer cell
  • Restoration of OPCML reverses the cancer state as well as activating anti-tumor immunity
  • It therefore functions in cancer like insulin for diabetes
  • OPCML tumor suppressor therapy synergizes with chemotherapy, RTK inhibitors and immunotherapy
  • Predictive biomarkers can select patients likely to benefit
  • In addition to tumor suppressor protein replacement therapy, gene replacement therapy can be considered
  • Initial lines of sight include brain, colorectal, and ovarian tumors